What is Chelation?

The term chelation is from the Greek root word 'chele', meaning 'claw'. Chelation therapy is considered an alternative medicine that has the purpose of removing 'heavy metals and toxins' from the body.

Why would someone experience heavy metal toxicity in the first place? Although it might sound like something only tied to rare circumstances of accidental poisoning, heavy metals are more common than you think. If you have mercury fillings in your teeth (or amalgam fillings), have been vaccinated to prevent various diseases, eat farm-raised fish regularly, consume foods that are grown in foreign countries (like China) that aren’t certified organic, or are healing from radiation and chemotherapy treatments, you’re likely experiencing heavy metal toxicity right now to some degree.

Chelation therapy can involve a chemical solution called EDTA (ethylenediaminetetraacetic acid), DMPS, Glutathione, Metallothionein or Vitamin C which is administered into the body — usually directly injected into the bloodstream — so it can bind with excess minerals. Once bound to “toxins” in the body, the chelation agents help detox the body of heavy metals by removing them before imbalances and illnesses have the chance to develop.

First developed and used in the 1950s for the treatment of heavy metal poisoning, chelation therapy using EDTA and or other chelation agents are used to remove common heavy metals, including lead, mercury, copper, iron, arsenic, aluminum and calcium. While still a controversial practice in mainstream medicine and one that requires more research for us to fully understand how it works, studies show that chelation therapy has potential for reducing the risk of heightened inflammation, heart disease, infections and more.

A National Health Interview Survey conducted by the Centers for Disease Control and Prevention found that 111,000 adults 18 years or older had used chelation therapy as a form of complementary medicine between the years 2006–2007. Since the popularity of chelation therapy has grown since this time and more health care professionals are being trained in this practice, it’s safe to say that this number is steadily rising.

How Chelation Therapy Works

Many people who have used chelation therapy regularly feel that it helps them remain more energetic and immune to common illnesses, environmental toxins and stress. Studies show that chelation is scientifically proven to rid the body of excess or toxic metals, especially certain kinds like lead or mercury that can lead to poisoning. The U.S. Food and Drug Administration has approved the use of chelation therapy with EDTA for treating lead poisoning and continues to investigate its potential and safety as a new drug for reducing coronary heart disease symptoms.

EDTA is a type of man-made synthetic amino acid. As an alternative, some practitioners also use another substance in EDTA’s place called DMPS (2,3-Dimercapto-1-propanesulfonic acid), which works similarly. EDTA chelation therapy works by binding salts to molecules in the blood once EDTA is administered into someone’s veins. After EDTA attaches to heavy metals, together they both move to the kidneys where they are eliminated from the body through urine.

It’s possible that “chelating agents” like EDTA and DMPS can help detoxify the body of toxic elements that contribute to many types of chronic diseases. Chelating agents have specific bonds that form between organic molecules and metals. This gives them the ability to “bind” to metals that build up in the blood, major organs and blood vessels.

Some chelating agents, including peptides like glutathione and metallothionein and Vitamin C have been well-researched and proven to transport and excrete toxins from the body, all without the need for expensive surgeries and risky medications.

The biggest benefit of chelation therapy is controlling levels of various environmental metals. Metals, including lead, mercury, aluminum and arsenic, can cause short- and long-term health consequences since they impact functions of the central nervous, cardiovascular, immune and skeletal systems. When the body is out of homeostasis due to experiencing imbalances in minerals, malfunction and damage to vital organs can develop.

Some of the most symptoms of heavy metal toxicity include:

5 Benefits of Chelation Therapy

1. Might Help Improve Heart Health

Although ongoing research is still underway, some alternative health care providers use chelation therapy to help treat coronary heart diseases, including atherosclerosis (thickening and hardening of the arteries that can potentially lead to a heart attack or stroke).

It’s believed that EDTA binds with calcium within the arteries, helping reduce plaque build-up and deposits that can cut off blood flow. Once bound to calcium, EDTA can help carry the molecules out of arteries so circulation improves. In a similar way, EDTA might help control high inflammation and cholesterol levels, which also pose a risk for heart disease. In the future, we might see chelation therapy used a less risky and more affordable alternative to heart surgery and complicated mediations that have many side effects.

2. Acts Like an Antioxidant

EDTA might act similarly to antioxidants by reducing inflammation, fighting free radical damage and removing metals that cause the foundation of chronic disease development. It’s been suggested that EDTA binds to not only calcium within arteries, but also other metals stored within bones, muscles and bodily tissues that can lead to increased inflammation or pain.

Certain chelating agents have even been used to successfully lower the presence of plutonium radiation toxicity within the body, which is tied to increased cancer risk. Uranium and radionuclide are two types of chemicals that can cause toxicity, leukemia and osteosarcoma when someone experiences long-term radiation exposure, but chelating agents, including DTPA, are able to help remove these before serious illnesses can form.

3. Lowers Pain and Swelling

Since chelation therapy targets inflammation, the root of most diseases, including arthritis and many autoimmune disorders, many people report less pain from inflamed muscles, joints and bones when using EDTA.

Although this theory hasn’t yet been proven in controlled scientific studies, chelation therapy might work by helping to reduce the effects of oxygen ions (also called oxidative stress) that can damage blood vessels and tissue. When inflammation causes the walls of vessels to become clogged, circulation decreases and pain grows. Chelation therapy can offer an alternative to ongoing medication treatments for chronic pain.

4. Can Help Fight Cognitive Disorders 

There’s evidence that chelation therapy can successfully treat cognitive disorders, including Alzheimer’s disease, multiple sclerosis and Parkinson’s disease. While the exact mechanisms in which EDTA helps resolve these problems isn’t yet clear or proven in studies, there seems to be a tie between heavy metal poisoning (or toxicity), including high levels of lead or mercury in the blood, and medical disorders that affect the brain, memory and learning.

Research also shows that increased accumulation in the brain of copper, iron and zinc might be associated with a number of neurodegenerative diseases. Long-term heavy metal exposure can lead to physical, muscular and neurological degenerative changes in the brain that set the stage for not only Alzheimer’s disease, but also dementia, Parkinson’s disease and multiple sclerosis.

5. Helps Lower Risk for Learning Disabilities

Sadly, rates of learning disabilities symptoms like ADHD and autism spectrum disorders have been on the rise in recent years, yet how exactly these conditions should be treated or prevented remains controversial in the medical community. Many practitioners are now looking to alternative treatment methods to control symptoms of cognitive disorders, including some like chelation therapy that target heavy metal poisoning.

While not technically authorized to be used for treating such conditions, “off-label use” of chelation therapy might be beneficial for cognitive health because of its proven ability to lower circulating or stored toxic metals that interfere with brain function. Going forward, we should expect to see new proven strategies using chelating agents that are capable of crossing the blood-brain barrier and bringing back homeostasis of minerals levels.

How Chelation Therapy Is Performed

Chelation therapy sessions take several hours to complete and are usually performed in a doctor’s office under special monitoring. Most patients need between five to 30 treatments for best results. Each treatment session involves insertion of an intravenous (IV) to administer liquid  usually into a vein located in the hand or arm.

The procedure isn’t painful for most people, but like with all injections, it’s possible to feel some burning, redness or swelling at the injection site. There isn’t much recovery time needed after the procedure and most patients are free to drive themselves home and go about their normal day. Some people report needing to urinate more than usual following chelation therapy, which can be beneficial considering this is how heavy metals leave the body.

Side Effects of Chelation Therapy

The most common side effect is a burning sensation at the site where EDTA is injected into a vein, but this usually goes away quickly and is mild. Some people also experience digestive issues like vomiting, feeling dizzy, fever, headaches, nausea, low blood sugar symptoms and blood pressure changes.

It’s very important for EDTA to be infused slowly, since high levels can cause electrolyte imbalances. It’s also possible that while it removes unwanted heavy metals, EDTA can potentially also bind to needed vitamins and minerals and remove them from the body, which poses the risk for deficiencies. To make up for this, many practitioners give patients large doses of vitamins/minerals following chelation therapy so they avoid becoming very deficient.

Although it’s very rare, kidney damage and heart failure can also occur due to blood pressure levels dropping suddenly and abnormally low calcium levels in the blood (hypocalcemia). At this time, children, pregnant women, and anyone who has a history of heart disease or kidney problems should not use chelation therapy without consulting with a doctor first.

Other Ways to Lower Heavy Metal Toxicity

If you’re experiencing symptoms of toxicity described above, chelation therapy combined with a reduction to common toxins is the best solution. How can you lower your exposure to heavy metals in the first place? Start by adjusting your diet, and then consider taking supplements that can also help.

Lower heavy metals in your diet by limiting or avoiding these foods:

  • Farmed fish, which can contain mercury or other heavy metals, dioxins and PCBs found in aluminum cans

  • Common food sensitivities and allergens like gluten and conventional dairy (when your immune system is working on fighting allergens, it has less energy available to detoxify the body)

  • Non-organic foods, which contain chemical pesticides

  • GMO foods (especially corn and soy)

  • Packages/processed foods that contain many synthetic ingredients and additives

  • Alcohol, which makes it harder for your liver to process other toxins


Here at Health+Plus

All patients will receive a thorough exam, blood work and a specific treatment plan to treat heavy metal toxicity. Typically we utilize High Dose Vitamin C as our chelating agent.


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